International Workshop on the Causes of Childhood Leukemia

Preliminary programme

Wednesday| November 20

from 11:00Registration │ Welcome coffee & snacks
SPECIAL SESSION: ANIMAL MODELS
Chair: Ximena Vergara, USA
12:00 – 12:30Introductions & Purpose: Why are we here?
Ximena Vergara, USA
12:30 - 13.00Childhood acute lymphoblastic leukemia - an overview and the challenges of modeling using human progenitors
Shai Izraeli, Israel
13.00 - 13.30Stem-cell based animal model of Childhood pB-ALL
César Cobaleda, Spain
13.30 - 14.00Cdkn2a deficient & Cdkn2a deficient/ETV6-RUNX1 mouse models of lymphoblastic leukemia
Scott Kogan, USA
14.00 - 14.30PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice
Cyril Broccardo, France
14.30 - 15.30 Discussion - Speaker Panel
Moderated by Ximena Vergara, Shai Izraeli and Kerry Broom
15:30 – 16:00Coffee break
SESSION 1: OPENING AND INTRODUCTION
Chair: Federal Office for Radiation Protection
16.00 - 16.15Welcome, short history and scope of the workshop
Gunde Ziegelberger, Federal Office for Radiation Protection
16.15 - 16.30Federal Office for Radiation Protection activities: Summary of pilot projects
Sabine Hornhardt, Federal Office for Radiation Protection
16.30 - 17.15Magnetic fields and childhood leukemia
Maria Feychting, Sweden
17.15 - 18.00Review of ionizing radiation and childhood leukemia
Ben Spycher, Switzerland
From 19.00Informal Get-together | Weißbräu Huber | General-von-Nagel-Straße 5, 85354 Freising

Thursday| November 21

SESSION 2: GENETIC AND EPIGENETIC FACTORS
Chair: Federal Office for Radiation Protection
09.00 - 09.30 Infections-driven B-precursor leukaemias are mediated by Activation Induced Deaminase (AID)-independent mechanisms
Arndt Borkhardt, Germany
09.30 - 10.00 Pre-leukemic clones in healthy newborns
Ute Fischer, Germany
10.00 - 10.30 Host genomics in acute leukemia of childhood
Julia Hauer, Germany
10.30 - 11.00 Coffee break
11.00 - 11.30 Cell-of-origin and immunotherapeutic targets for MLLr B-ALL
Pablo Menéndez, Spain
11.30 - 12.00 Environmental Exposures and Childhood Leukemia - DNA methylation as a Mediating Mechanism
Jill McKay, UK
12.00 - 12.30 The Making of Leukemia: Epigenetic Priming in Leukemia Initiation
Isidro Sánchez-García, Spain
Short Talk
12.30 - 12.45 A rare RAD21 mutation in a family with history of cancer
Franziska Auer, Germany
12.45 - 13.45 Lunch break
SESSION 3: ROLE OF THE IMMUNE SYSTEM
Chair: Federal Office for Radiation Protection
13:45– 14:15 Maternal infections during pregnancy and childhood leukaemia: A systematic review of previous evidence and a pooled analysis from six international birth cohorts
Jianrong He, UK
14.15- 14.45 Inflammation favors ETV6-RUNX1 positive pre-leukemia in a model of bone marrow niche
Giovanni Cazzaniga, Italy
14.45- 15.15 B-cell identity as a metabolic barrier against malignant transformation
Lai N. Chan, USA
15.15- 15.45 Coffee break
SHORT TALKS
Chair: Federal Office for Radiation Protection
15.45- 16.00 Commensal gut microbiota protects from infection driven acute lymphoblastic leukemia
Carolina Vicente-Dueñas, Spain
16.00 - 16.15 The role of extracellular vesicles in ionizing radiation induced bone marrow pathologies
Katalin Lumniczky, Hungary
16.15 - 16.30 Ionizing radiation induces AML related changes in the cargo of extracellular vesicles from haematopoetic system
Tunde Szatmari, Hungary
16.30 - 17.00 POSTER SESSION
From 19.00 Conference Dinner
Bräustüberl │ Weihenstephaner Berg 10, 85354 Freising

Friday | November 22

SESSION 4: ENVIRONMENTAL RISK FACTORS
Chair: Federal Office for Radiation Protection
09.00 - 09.30

New Results from the Childhood Leukemia International Consortium (CLIC)
Joachim Schüz, France

09.30 - 10.00 Current research and future opportunities in the International Childhood Cancer Cohort Consortium
Terry Dwyer, Australia/UK
10.00 - 10.30 Space-time Clustering of Childhood Leukaemia: A Systematic Review and Pooled Analysis
Christian Kreis, Switzerland
10.30 - 11.00 Coffee break
SPECIAL SESSION: BACKGROUND RADIATION
Chair: Ben Spycher
11.00 - 11.20 An update on the study of childhood cancer and natural radiation in Great
Gerald Kendall, UK
11.20 - 11.40 New results from France
Stéphanie Goujon France
11.40 - 12.00 Background Ionizing Radiation and the Risk of Childhood Cancer: A Census-Based Nationwide Cohort Study - New Results from Switzerland
Antonella Mazzei, Switzerland
12.00 - 13.00

Small lunch

SESSION 5: LOOKING AROUND AND FORWARD –WHAT TO DO NEXT?
Chair: Federal Office for Radiation Protection
13.00 - 13.30 Variations and trends in incidence of lymphoid leukaemia in children: Results from 131 population-based cancer registries around the globe
Friederike Erdmann, Denmark
13.30 - 14.30 Summing up/Discussion
Federal Office for Radiation Protection & Joachim Schüz

The preliminary programme is available here.